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Forensic Medicine Lecture
Research room overview
The current 6th Professor, Toshikazu Kondo, left Kanawaza University for his new post at Wakayama Medical University in April 2003.? Our research room has been in operation since the first professor, Toji Doi, took his post, followed by Professor Toru Suzutani, Professor Taizo Nagano, Professor Choei Wakasugi, and Professor Tsutomu Tsuji.
After Professor Kondo became in charge, we have performed over 100 forensic autopsies, and its number has been increasing, exceeding 150 autopsies in 2007.? We currently perform well over 200 autopsies a year.? Although we are busy with our daily forensic practice, as the only organization to perform forensic autopsies in Wakayama prefecture, we do our best to fulfill great responsibilities by playing an important role in supporting the social justice.? Needless to say, we work not only on forensic practice, but also on education and research.? We develop research from forensic medicine to state-of-the-art cell biology under a large theme of “invasion and biological response.”? To be specific, our research includes an application of determining elapsed time after skin damage, of which indicators are cytokine and chemokine, to forensic practice.? Additionally, we aim to reveal the molecular mechanism of skin injury healing and molecular pathophysiology of traumatic shock and drug addiction using genetically modified animals. ?We aggressively present the research outcomes not only in the field of forensic medicine, but also in fields other than forensic medicine, and we are proud to be highly commended in each field. ?Furthermore, students in the MD-PhD program or those interested in forensic medicine constantly come and join us. ?We provide them with an environment to participate in on-the-ground research and forensic practice.? In this way, we are working to develop human resources as future leaders in forensic medicine.
Education overview
In order to analyze and figure out the cause of abnormal deaths that occurred in a group, we aim to have the students understand multiple points of contact between medicine and law in society and acquire an attitude to fulfill the duties of forensic medicine.
Our education contents include lectures on death and the elapsed time after death, damage and cause of death, suffocation, intoxication, damages from traffic accident, abnormal death of infants, death under abnormal circumstances, sudden unexpected natural death, abnormalities related to sex, and identification of individuals in a group.? Also, we demonstrate blood typing, show and explain autopsies by using slides, and provide opportunities to observe as many autopsies as possible to promote students’ comprehensive understanding.
Research overview
In order to analyze the roles of bioactive substances, such as cytokine and chemokine in biological response to external stimuli, we develop disorder and pathological models that are considered essential for the analyses, which we perform by using genetically modified mice.
- Skin injury healing model
- Acute or chronic pulmonary disorder model
- Acute hepatic disorder model
- Acute renal disorder model
- Acute pancreatic disorder model
Achievements
- 2016
- 2015
- 2013
- 2012
- 2011
- 2010
- 2009
- 2008
- 2007
- 2006
- 2005
- 2004
- 2003
- Kimura A, Ishida Y, Nosaka M, Kuninaka Y, Hama M, Kawaguchi T, Sakamoto S, Shinozaki K, Iwahashi Y, Takayasu T, Kondo T. Exaggerated arsenic nephrotoxicity in female mice through estrogen-dependent impairments in the autophagic flux. Toxicology, 339:9-18. 2016
- Shimomatsu T, Kanazawa N, Mikita N, Nakatani Y, Li HJ, Inaba Y, Ikeda T, Kondo T, Furukawa F. The effect of hydroxychloroquine on lupus erythematosus-like skin lesions in MRL/lpr mice. Mod Rheumatol. Early Online: 1–5. 2016
- Kimura A, Ishida Y, Nosaka M, Shiraki M, Hama M, Kawaguchi T, Kuninaka Y, Shimada E, Yamamoto H, Takayasu T, Kondo T. Autophagy in skin wounds: a novel marker for vital reactions. Int J Legal Med, 129:537-541. 2015
- Ishida Y, Kuninaka Y, Nosaka M, Kimura A, Kawaguchi T, Hama M, Sakamoto S, Shinozaki K, Eisenmenger W, Kondo T. Immunohistochemical analysis on MMP-2 and MMP-9 for wound age determination. Int J Legal Med, 129:1043-1048. 2015
- Ishida Y, Kimura A, Nosaka M, Kuninaka Y, Shimada E, Yamamoto H, Nishiyama K, Inaka S, Takayasu T, Eisenmenger W, Kondo T. Detection of endothelial progenitor cells in human skin wounds and its application for wound age determination. Int J Legal Med, 129:1049-1054. 2015
- Nosaka M, Ishida Y, Kimura A, Hama M, Kawaguchi T, Yamamoto H, Kuninaka Y, Shimada E, Kondo T. Immunohistochemical detection of intrathrombotic IL-6 and its application to thrombus age estimation. Int J Legal Med, 129:1021-1025. 2015
- Kobayashi A, Tanizaki Y, Kimura A, Ishida Y, Nosaka M, Toujima S, Kuninaka Y, Minami S, Ino K, Kondo T. AG490, a Jak2 inhibitor, suppressed the progression of murine ovarian Cancer. Eur J Pharmacol, 766:63-75. 2015
- Wang Y, Yamamoto Y, Kuninaka Y, Kondo T, Furukawa F. Forensic Potential of MMPs and CC Chemokines for Wound Age Determination. J Forensic Sci, 60:1511-1515. 2015
- Nosaka M, Ishida Y, Kimura A, Kondo T. Immunohistochemical detection of intrathrombotic macrophage-derived cytokines and its application to thrombus age estimation in murine deep vein thrombosis model. Int J Legal Med, 127:937-942. 2013
- Kawaguchi T, Hama M, Abe M, Suenaga T, Ishida Y, Nosaka M, Kuninaka Y, Kawaguchi M, Yoshikawa N, Kimura A, Kondo T. Sudden unexpected neonatal death due to late onset group B streptococcal sepsis-A case report. Leg Med (Tokyo), 15:260-263. 2013
- Ishida Y, Kimura A, Kuninaka Y, Inui M, Matsushima K, Mukaida N, Kondo T. Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing. J Clin Invest, 122:711-721. 2012
- Kimura A, Ishida Y, Inagaki M, Nakamura Y, Sanke T, Mukaida N, Kondo T. Interferon-g is protective in cisplatin-induced renal injury by enhancing autophagic flux. Kidney Int, 82 : 1093-1104. 2012
- Hama M, Abe M, Kawaguchi T, Ishida Y, Nosaka M, Kuninaka Y, Kimura A, Kondo T. A case of myocardial infarction in a young female with subclinical hyperthyroidism. Int J Cardiol, 158:e23-25. 2012
- Ishida Y, Kimura A, Nosaka M, Kuninaka Y, Takayasu T, Eisenmenger W, Kondo T. Immunohistochemical analysis on cyclooxygenase-2 for wound age determination. Int J Legal Med, 126: 435-440. 2012
- Nosaka M, Ishida Y, Kuninaka Y, Kimura A, Kondo T. Immunohistochemical detection of uPA, tPA, and PAI-1 in a stasis-induced deep vein thrombosis model and its application to thrombus age estimation. Int J Legal Med, 126: 421-425. 2012
- Takayasu T, Ishida Y, Nosaka M, Kawaguchi M, Kuninaka Y, Kimura A, Kondo T. High concentration of methidathion detected in a fatal case of organophosphate-poisoning. Leg Med (Tokyo) 14:263-266. 2012
- Lu P, Li L, Liu G, Baba T, Ishida Y, Nosaka M, Kondo T, Zhang X, Mukaida N. Critical role of TNF-α-induced macrophage VEGF and iNOS production in the experimental corneal neovascularization. Invest Ophthalmol Vis Sci, 53:3516-3526. 2012
- Hama-Tomioka K, Kinoshita H, Nakahata K, Kondo T, Azma T, Kawahito S, Hatakeyama N, Matsuda N. Roles of neuronal nitric oxide synthase, oxidative stress, and propofol in N-methyl-D-aspartate-induced dilatation of cerebral arterioles. Br J Anaesth, 108:21-29. 2012
- Hirai Y, Muragaki Y, Itoh S, Oikawa K, Juri M, Kondo T, Okamura Y. Fibulin-5 protein is reduced in the lung of patients with spontaneous pneumothorax who are under 25 years old. Ann Thorac Cardiovasc Surg, 18: 200-205. 2012
- Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Inui M, Mukaida N, Kondo T. Absence of IFN-g accelerates thrombus resolution through enhanced MMP-9 and VEGF expression in mice. J Clin Invest, 121:2911-2920. 2011
- Inui M, Ishida Y, Kimura A, Kuninaka Y, Mukaida N, Kondo T. Protective roles of CX3CR1-mediated signals in toxin A-induced enteritis through the induction of heme oxygenase-1 expression. J Immunol, 186:423-431. 2011
- Kimura A, Ishida Y, Hayashi T, Nosaka M, Kondo T. Estimating time of death based on the biological clock. Int J Legal Med, 125:385-391. 2011
- An JL, Ishida Y, Kimura A, Kondo T. Immunohistochemical examination of intracerebral aquaporin-4 expression and its application for differential diagnosis between freshwater and saltwater drowning. Int J Legal Med, 125:59-65. 2011
- Fujii H, Baba T, Ishida Y, Kondo T, Yamagishi M, Kawano M, Mukaida N. Ablation of the Ccr2 gene exacerbates polyarthritis in interleukin-1 receptor antagonist-deficient mice. Arthritis Rheum, 63:96-106. 2011
- Morita S, Sakagashira S, Shimajiri Y, Eberhardt NL, Kondo T, Sanke T. Autophagy protects against human islet amyloid polypeptide-associated apoptosis. J Diabetes Invest, 2:48-55. 2011
- 近藤稔和,石田裕子. 皮膚損傷の受傷後経過時間判定の研究と実際.法医病理,17:43-50. 2011
- Kimura A, Ishida Y, Wada T, Hisaoka T, Morikawa Y, Sugaya T, Mukaida N, Kondo T. The absence of interleukin-6 enhanced arsenite-induced renal injury by promoting autophagy of tubular epithelial cells with aberrant extracellular signal-regulated kinase activation. Am J Pathol, 176:40-50. 2010
- Kostadinova FI, Baba T, Ishida Y, Kondo T, Popivanova BK, Mukaida N. Crucial involvement of the CX3CR1-CX3CL1 axis in dextran sulfate sodium-mediated acute colitis in mice. J Leukoc Biol, 88:133-143. 2010
- Nosaka M, Ishida Y, Kimura A, Kondo T. Immunohistochemical detection of MMP-2 and MMP-9 in a stasis-induced deep vein thrombosis model and its application to thrombus age estimation. Int J Legal Med, 124:439-444. 2010
- An JL, Ishida Y, Kimura A, Kondo T. Forensic application of intrarenal aquaporin-2 expression for differential diagnosis between freshwater and saltwater drowning. Int J Legal Med, 124:99-104. 2010
- Kondo T, Ishida Y. Molecular pathology of wound healing. Forensic Sci Int, 203:93-98. 2010
- Nosaka M, Ishida Y, Kimura A, Kondo T. Time-dependent organic changes of intravenous thrombi in stasis-induced deep vein thrombosis model and its application to thrombus age determination. Forensic Sci Int, 195:143-147. 2010
- Takayasu T, Ishida Y, Kimura A, Nosaka M, Kawaguchi M, Kondo T. Postmortem distribution of ametryn in the blood and organ tissues in a herbicide-poisoning case. J Anal Toxicol, 34:287-291. 2010
- Takayasu T, Ishida Y, Kimura A, Nosaka M, Kuninaka Y, Kawaguchi M, Kondo T. Distribution of carbamazepine and its metabolites carbamazepine-10,11-epoxide and iminostilbene in body fluids and organ tissues in five autopsy cases. Forensic Toxicol, 28:124–128. 2010
- Toyozawa S, Yamamoto Y, Ishida Y, Kondo T, Nakamura Y, Furukawa F. Immunohistochemical analysis of CXCR4 expression in fibrohistiocytic tumors. Acta Histochem Cytochem, 43:45-50. 2010
- Ishibe T, Kimura A, Ishida Y, Takayasu T, Hayashi T, Tsuneyama K, Matsushima K, Sakata I, Mukaida N, Kondo T. Reduced acetaminophen-induced liver injury in mice by genetic disruption of IL-1 receptor antagonist. Lab Invest, 89:68-79. 2009
- Popivanova BK, Kostadinova FI, Furuichi K, Shamekh MM, Kondo T, Wada T, Egashira K, Mukaida N. Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice. Cancer Res, 69:7884-7892. 2009
- Hayashi T, Ishida Y, Mizunuma S, Kimura A, Kondo T. Differential diagnosis between freshwater drowning and saltwater drowning based on intrapulmonary aquaporin-5 expression. Int J Legal Med, 123:7-13. 2009
- Ishida Y, Kimura A, Takayasu T, Eisenmenger W, Kondo T. Detection of fibrocytes in human skin wounds and its application for wound age determination. Int J Legal Med, 123:299-304. 2009
- Nosaka M, Ishida Y, Kimura A, Kondo T. Time-dependent appearance of intrathrombus neutrophils and macrophages in a stasis-induced deep vein thrombosis model and its application to thrombus age determination. Int J Legal Med, 123:235-240. 2009
- An JL, Ishida Y, Kimura A, Tsokos M, Kondo T. Immunohistochemical detection of CCR2 and CX3CR1 in sepsis-induced lung injury. Forensic Sci Int, 192:e21-25. 2009
- Kaminaka C, Yamamoto Y, Yonei N, Kishioka A, Kondo T, Furukawa F. Phenol peels as a novel therapeutic approach for actinic keratosis and Bowen disease: prospective pilot trial with assessment of clinical, histologic, and immunohistochemical correlations. J Am Acad Dermatol, 60:615-625. 2009
- Ishida Y, Gao JL, Murphy PM. Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and function. J Immunol, 180:569-579. 2008
- Ishida Y, Hayashi T, Goto T, Kimura A, Akimoto S, Mukaida N, Kondo T. Essential involvement of CX3CR1-mediated signals in the bactericidal host defense during septic peritonitis. J Immunol, 181:4208-4218. 2008
- Popivanova BK, Kitamura K, Wu Y, Kondo T, Kagaya T, Kaneko S, Oshima M, Fujii C, Mukaida N. Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest, 118:560-570. 2008
- Nosaka M, Ishida Y, Tanaka A, Hayashi T, Miyashita T, Kaminaka C, Eisenmenger W, Furukawa F, Kimura A. Aberrant expression of histo-blood group A type 3 antigens in vascular endothelial cells in inflammatory sites. J Histochem Cytochem, 56:223-231. 2008
- Ishida Y, Kimura A, Takayasu T, Eisenmenger W, Kondo T. Expression of oxygen-regulated protein 150 (ORP150) in skin wound healing and its application for wound age determination. Int J Legal Med, 122:409-414. 2008
- Fukube S, Hayashi T, Ishida Y, Kamon H, Kawaguchi M, Kimura A, Kondo T. Retrospective study on suicidal cases by sharp force injuries. J Forensic Leg Med, 15:163-167. 2008
- Ikematsu K, Takahashi H, Kondo T, Tsuda R, Nakasono I. Temporal expression of immediate early gene mRNA during the supravital reaction in mouse brain and lung after mechanical asphyxiation. Forensic Sci Int, 179:152-156. 2008
- Takayasu T, Ishida Y, Kimura A, Kawaguchi M, Kondo T. Distribution of zolpidem in body fluids and organ tissues in five autopsy cases. Forensic Toxicol, 26:80-84. 2008
- Takayasu T, Hayashi T, Ishida Y, Nosaka M, Mizunuma S, Miyashita T, Kawaguchi M, Kimura A, Kondo T. A fatal intoxication from ingestion of 2-methyl-4-chlorophenoxyacetic acid (MCPA). J Anal Toxicol, 32:187-191. 2008
- Nakahata K, Kinoshita H, Hama-Tomioka K, Ishida Y, Matsuda N, Hatakeyama N, Haba M, Kondo T, Hatano Y. Cholinesterase inhibitor donepezil dilates cerebral parenchymal arterioles via the activation of neuronal nitric oxide synthase. Anesthesiology, 109:124-129. 2008
- Kiguchi N, Maeda T, Kobayashi Y, Kondo T, Ozaki M, Kishioka S. The critical role of invading peripheral macrophage-derived interleukin-6 in vincristine-induced mechanical allodynia in mice. Eur J Pharmacol, 592:87-92. 2008
- Zhu BM, Ishida Y, Robinson GW, Pacher-Zavisin M, Yoshimura A, Murphy PM, Hennighausen L. SOCS3 Negatively Regulates the gp130-STAT3 Pathway in Mouse Skin Wound Healing. J Invest Dermatol, 128:1821-1829. 2008
- Hayashi T, Ishida Y, Kimura A, Iwakura Y, Mukaida N, Kondo T. IFN-g protects cerulein-induced acute pancreatitis by repressing NF-kB activation. J Immunol, 178:7385-7394. 2007
- Ishida Y, Kimura A, Kondo T, Hayashi T, Ueno M, Takakura N, Matsushima K, Mukaida N. Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration. Am J Pathol, 170:843-854. 2007
- Ishida Y, Kimura A, Kondo T, Hayashi T, Ueno M, Takakura N, Matsushima K, Mukaida N. Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration. Am J Pathol, 170:843-854. 2007
- Hayashi T, Ishida Y, Kimura A, Iwakura Y, Mukaida N, Kondo T. IFN-g protects cerulein-induced acute pancreatitis by repressing NF-κB activation. J Immunol, 178:7385-7394. 2007
- Hayashi T, Hirayama N, Ro A, Kageyama N, Ishida Y, Tsuneyama K, Kimura A, Fukunaga T, Kondo T. Severe brainstem compression by an unruptured giant vertebral aneurysm--an autopsy case. Leg Med, 9:322-325. 2007
- Miyashita T, Hayashi T, Ishida Y, Tsuneyama K, Kimura A, Kondo T. A fatal case of pontine hemorrhage related to methamphetamine abuse. J Forensic Leg Med, 14:444-447. 2007 Former title: Formerly known as the Journal of Clinical Forensic Medicine.
- Nakaya I, Wada T, Furuichi K, Sakai N, Kitagawa K, Yokoyama H, Ishida Y, Kondo T, Sugaya T, Kawachi H, Shimizu F, Narumi S, Haino M, Gerard C, Matsushima K, Kaneko S. Blockade of IP-10/CXCR3 promotes progressive renal fibrosis. Nephron Exp Nephrol, 107:e12-21. 2007
- Ogata M, Ago K, Ago M, Kondo T, Kasai K, Ishikawa T, Mizukami H. A Fatal Case of Hypothermia Associated With Hemorrhages of the Pectoralis Minor, Intercostal, and Iliopsoas Muscles. Am J Forensic Med Pathol, 28:348-352. 2007
- 小片 守,吾郷一利,吾郷美保子,中島弘志,池松和哉,近藤稔和,北 敏郎,田中宣幸.高齢者虐待―身体的?経済的虐待が原因で自殺したと判断された一剖検例―.犯罪学雑誌,73:208-213. 2007
- 石田裕子,向田直史,近藤稔和.皮膚損傷治癒とIL-1 receptor antagonist(IL-1ra).臨床免疫?アレルギー科.47:245-251. 2007 (解説)
- Ishida Y, Kondo T, Kimura A, Matsushima K, Mukaida N. Absence of IL-1 receptor antagonist impaired wound healing along with aberrant NF-?B activation and a reciprocal suppression of TGF-? signal pathway. J Immunol, 176:5598-5606. 2006
- Kimura A, Ishida Y, Hayashi T, Wada T, Yokoyama H, Sugaya T, Mukaida N, Kondo T. Interferon-? plays protective roles in sodium arsenite-induced renal injury by up-regulating intrarenal multidrug resistance-associated protein 1 expression. Am J Pathol, 169:1118-1128. 2006
- Ishida Y, Kondo T, Kimura A, Tsuneyama K, Takayasu T, Mukaida N. Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury. Eur J Immunol, 36:1028-1038. 2006
- Yang X, Lu P, Ishida Y, Kuziel WA, Fujii C, Mukaida N. Attenuated liver tumor formation in the absence of CCR2 with a concomitant reduction in the accumulation of hepatic stellate cells, macrophages and neovascularization. Int J Cancer, 118:335-345. 2006
- Ishida Y, Takayasu T, Kimura A, Hayashi T, Kakimoto N, Miyashita T, Kondo T. Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice. Leg Med (Tokyo), 8:102-109. 2006
- Kimura A, Ishida Y, Hayashi T, Wada T, Yokoyama H, Sugaya T, Mukaida N, Kondo T. Interferon-g plays protective roles in sodium arsenite-induced renal injury by up-regulating intrarenal multidrug resistance-associated protein 1 expression. Am J Pathol, 169:1118-1128. 2006
- Ishida Y, Kondo T, Kimura A, Matsushima K, Mukaida N. Absence of IL-1 receptor antagonist impaired wound healing along with aberrant NF-kB activation and a reciprocal suppression of TGF-b signal pathway. J Immunol, 176:5598-5606. 2006
- Ishida Y, Takayasu T, Kimura A, Hayashi T, Kakimoto N, Miyashita T, Kondo T. Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice. Leg Med(Tokyo), 8:102-109. 2006
- Ishida Y, Kondo T, Kimura A, Tsuneyama K, Takayasu T, Mukaida N. Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury. Eur J Immunol, 36:1028-1038. 2006
- Yang X, Lu P, Ishida Y, Kuziel WA, Fujii C, Mukaida N. Attenuated liver tumor formation in the absence of CCR2 with a concomitant reduction in the accumulation of hepatic stellate cells, macrophages and neovascularization. Int J Cancer, 118:335-345. 2006
- Takahara A, Sugiyama A, Ishida Y, Satoh Y, Wang K, Nakamura Y, Hashimoto K. Long-term bradycardia caused by atrioventricular block can remodel the canine heart to detect the histamine H1 blocker terfenadine-induced torsades de pointes arrhythmias. Br J Pharmacol, 147:634-641. 2006
- Miyashita T, Kakimoto N, Ishida Y, Hayashi T, Kimura A, Tsokos M, Kondo T. Immunohistochemical expression of tumor necrosis factor-a in sepsis-induced lung injury. Forensic Sci Med Pathol, 2:103-108. 2006
- Nakahata K, Kinoshita H, Tokinaga Y, Ishida Y, Kimoto Y, Dojo M, Mizumoto K, Ogawa K, Hatano Y. Vasodilation mediated by inward rectifier K+ channels in cerebral microvessels of hypertensive and normotensive rats. Anesth Analg, 102:571-576. 2006
- Rieg S, Seeber S, Steffen H, Humeny A, Kalbacher H, Stevanovic S, Kimura A, Garbe C, Schittek B. Generation of multiple stable dermcidin-derived antimicrobial peptides in sweat of different body sites. J Invest Dermatol, 126:354-365. 2006
- Kimura A, Kanekura T, Saito Y, Sagawa K, Nosaka M, Kanzaki T, Tsuji T. Blood group A glycosphingolipid accumulation in the hair of patients with α-N-acetylgalactosaminidase deficiency. Life Sci 76:1817-1824. 2005
- Hayashi T, Ishida Y, Miyashita T, Kiyokawa H, Kimura A, Kondo T. Fatal water intoxication in a schizophrenic patient--an autopsy case. J Clin Forensic Med, 12:157-159. 2005
- Kimura A, Ishida Y, Wada T, Yokoyama H, Mukaida N, Kondo T. MRP-1 expression levels determine strain-specific susceptibility to sodium arsenic-induced renal injury between C57BL/6 and BALB/c mice. Toxicol Appl Pharmacol, 203:53-61. 2005
- Takayasu T, Kondo T. Assessment of drug screening kit instacheck for human samples. Jpn J Fornsic Toxicol, 23:209-213. 2005
- Yukawa K, Kishino M, Hoshino K, Shirasawa K, Kimura A, Tsubota Y, Owada-Makabe K, Bai T, Tanaka T, Ueyama T, Ichinose M, Takeda K, Akira S, Maeda M. The kinase domain of death-associated protein kinase is inhibitory for tubulointerstitial fibrosis in chronic obstructive nephropathy. Int J Mol Med, 15:73-78. 2005
- Yukawa K, Kishino M, Goda M, Liang XM, Kimura A, Tanaka T, Bai T, Owada-Makabe K, Tsubota Y, Ueyama T, Ichinose M, Maeda M, Takeda K, Akira S. STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy. Int J Mol Med, 15:225-230. 2005
- 石田裕子,近藤稔和,向田直史.Clostridium difficile toxin A 誘発腸炎におけるサイトカインの役割-IFN-gの生物学的役割-.炎症?再生, 25:507-511. 2005
- Ishida Y, Maegawa T, Kondo T, Kimura A, Iwakura Y, Nakamura S, Mukaida N. Essential Involvement of IFN-γ in Clostridium difficile Toxin A-Induced Enteritis. J Immunol. 172:3018-3025. 2004
- Ishida Y, Kondo T, Takayasu T, Iwakura Y, Mukaida N. The Essential Involvement of Cross-Talk between IFN-γ and TGF-β in the Skin. Wound-Healing Process. J Immunol, 172:1848-1855. 2004
- Ishida Y, Kondo T, Tsuneyama K, Lu P, Takayasu T, Mukaida N. The pathogenic roles of tumor necrosis factor receptor p55 in acetaminophen-induced liver injury in mice. J Leukoc Biol, 75:59-67. 2004
- Hayashi T, Ishida Y, Kimura A, Takayasu T, Eisenmenger W, Kondo T. Forensic application of VEGF expression to skin wound age determination. Int J Legal Med, 118:320-325. 2004
- Ikematsu K, Tsuda R, Kondo T, Kondo H, Ozawa K, Ogawa S, Nakasono I. The expression of '150-kDa oxygen regulated protein (ORP-150)' in human brain and its relationship with duration time until death. Leg Med(Tokyo) , 6:97-101. 2004
- Mori R, Kondo T, Nishie T, Ohshima T, Asano M. Impairment of skin wound healing in b-1,4-galactosyltransferase-deficient mice with reduced leukocyte recruitment. Am J Pathol, 164: 1303-1314. 2004
- Kishino M, Yukawa K, Hoshino K, Kimura A, Shirasawa N, Otani H, Tanaka T, Owada-Makabe K, Tsubota Y, Maeda M, Akira S and Mune M. Deletion of the Kinase Domain in Death-Associated Protein Kinase Attenuates Tubular Cell Apoptosis in Renal Ischemia-Reperfusion Injury. J Am Soc Nephrol, 15:1826-1834. 2004
- Amano H, Morimoto K, Senba M, Wang H, Ishida Y, Kumatori A, Yoshimine H, Oishi K, Mukaida N, Nagatake T. Essential Contribution of Monocyte Chemoattractant Protein-1/C-C Chemokine Ligand-2 to Resolution and Repair Processes in Acute Bacterial Pneumonia. J Immunol. 172:398-407. 2004
- Wada T, Furuichi K, Sakai N, Iwata Y, Kitagawa K, Ishida Y, Kondo T, Hashimoto H, Ishiwata Y, Mukaida N, Tomosugi N, Matsushima K, Egashira K, Yokoyama H. Gene therapy via blockade of monocyte chemoattractant protein-1 for renal fibrosis. J Am Soc Nephrol, 15:940-948. 2004
- Nakamura M, Kyo S, Kanaya T, Yatabe N, Maida Y, Tanaka M, Ishida Y, Fujii C, Kondo T, Inoue M, Mukaida N. hTERT-promoter-based tumor-specific expression of MCP-1 effectively sensitizes cervical cancer cells to a low dose of cisplatin. Cancer Gene Ther, 11:1-7. 2004
- Tomita Y, Yang X, Ishida Y, Nemoto-Sasaki Y, Kondo T, Oda M, Watanabe G, Chaldakov GN, Fujii C, Mukaida N. Spontaneous regression of lung metastasis in the absence of tumor necrosis factor receptor p55. Int J Cancer, 112:927-933. 2004
- Minami Y, Uede K, Sagawa K, Kimura A, Tsuji T, Furukawa F. Immunohistochemical staining of cutaneous tumours with G-81, a monoclonal antibody to dermcidin. Br J Dermatol, 151:165-169. 2004
- Minami Y, Uede K, Furukawa F, Sagawa K, Kimura A, Tsuji T. Cutaneous mixed tumors: an immunohistochemical study using two antibodies, G-81 and C8/144B. J Dermatol Sci, 36:180-182. 2004
- Yukawa K, Shirasawa N, Ohshima A, Mune M, Kimura A, Tao Bai, Tsubota Y, Owada-Makabe K, Tanaka T, Kishino M, Tsuruo Y, Umesaki N, Maeda M. Death-associated protein Kinase localization to human renal tubule cells, and increased expression of chronic obstructive uropathy in rats. J Nephrol, 17:26-33. 2004
- Yukawa K, Hoshino K, Kishino M, Mune M, Shirasawa N, Kimura A, Tsubota Y, Owada-Makabe K, Tanaka T, Ichinose M, Maeda M, Takeda K, Akira S. Deletion of the kinase domain in death-associated protein kinase attenuates renal tubular cell apoptosis in chronic obstructive uropathy. Int J Mol Med 13:515-520. 2004
- 石田裕子,近藤稔和,向田直史.Clostridium difficile toxin A 誘発腸炎におけるIFN-gの役割.臨床免疫, 42:474-476. 2004
- 近藤稔和.皮膚創傷治癒-法医学から分子病理学.和歌山医学,55:2-6. 2004
- Tanaka J, Ishida Y, Ohshima T, Kondo T. The gene expression of cytokines and chemokines induced by tourniquet shock in mice. Leg Med, 5:146-155. 2003
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